detection of factor viii inhibitors in hemophilia a patients

نویسندگان

mohsin sh

jaffar j

hussain sh

suhail sh

چکیده

background: factor viii administration to hemophilia a patients results in an immune response (inhibitor formation) which significantly complicates the therapy. the present study was performed to determine the prevalence of inhibitor development in hemophilia a patients receiving recombinant factor viii therapy. materials and methods: this was an observational descriptive study. clotting factor inhibitor screening was performed by activated partial thromboplastin time mixing studies using normal pool plasma collected from twenty healthy donors. bethesda assay for quantitation of factor viii inhibitors was performed on samples which were positive with screening tests. results: out of 229 patients with hemophilia a enrolled in the hemophilia society of pakistan, lahore center, 50 patients were selected. the mean factor viii level in these patients was 2.46 +3.14. out of 50 patients, 29 (58%) had severe hemophilia a (factor viii level <1%), 17 (34%) had moderate hemophilia a (factor viii level 1-5%) and 4 (12%) had mild hemophilia a (factor viii level >5-30%). in this study, 12 patients (24%) were positive for inhibitors. most of them 9 (75%) were low responders (<5 bethesda units) with a mean bethesda units of 1.82+0.473, while 3 (25%) patients were high responders (>5 bethesda units) with a mean bu of 11.33+5.85. patients were divided into two groups on the basis of the number of factor viii concentrate therapies of <50 (group 1) times and >50 times (group 2). inhibitor positivity was high (34.5%) in group i, as compared to group ii (9.5%). bleeding episodes were also more common in inhibitors positive patients. conclusion: in this study, the inhibitor development in patients with hemophilia a receiving recombinant factor viii concentrates therapy was 24% and the first fifty therapies were crucial for inhibitor development. keywords: hemophilia a, inhibitors, bethesda units.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Detection of Factor VIII Inhibitors in Hemophilia A Patients

Background: Factor VIII administration to hemophilia A patients results in an immune response (inhibitor formation) which significantly complicates the therapy. The present study was performed to determine the prevalence of inhibitor development in hemophilia A patients receiving recombinant factor VIII therapy. Materials and Methods: This was an observational descriptive study. Clotting fac...

متن کامل

Factor VIII products and inhibitors in severe hemophilia A.

n engl j med 368;15 nejm.org april 11, 2013 1456 improves outcomes as compared with less complete revascularization.2 However, our trial involved highly experienced interventional cardiologists and surgeons who attempted to maximize the completeness of revascularization. Substantially more complete PCI-based revascularization is therefore unlikely in other institutions. Serruys and Farooq sugge...

متن کامل

High-dose factor VIII inhibits factor VIII-specific memory B cells in hemophilia A with factor VIII inhibitors.

Hemophilia A in its severe form is a life-threatening hemorrhagic disease that is caused by mutations in the factor VIII (FVIII) gene (symbol F8). About 25% of patients who receive replacement therapy develop neutralizing antibodies that inhibit the function of substituted FVIII. Long-term application of high doses of FVIII has evolved as an effective therapy to eradicate the antibodies and to ...

متن کامل

The Survey of Effective Agents on Factor VIII and IX Inhibitors in Patients with Hemophilia A and B in Kermanshah Province

  Background: Hemophilia is the most frequent severe hereditary hemorrhagic disease due to deficiency of coagulation factors VIII (Hemophilia A) or IX (Hemophilia B) in plasma. We aimed to identify patients with  hemophilia in Kermanshah, Iran and assess the incidence of inhibitors in this population and its associated factors. Methods: This study was conducted on patients with hemophilia...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of blood and cancer

جلد ۴، شماره ۴، صفحات ۱۶۳-۱۶۸

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023